GCH1 haplotype determines vascular and plasma biopterin availability in coronary artery disease effects on vascular superoxide production and endothelial function.

Journal article

OBJECTIVES: This study sought to determine the effects of endogenous tetrahydrobiopterin (BH4) bioavailability on endothelial nitric oxide synthase (eNOS) coupling, nitric oxide (NO) bioavailability, and vascular superoxide production in patients with coronary artery disease (CAD). BACKGROUND: GTP-cyclohydrolase I, encoded by the GCH1 gene, is the rate-limiting enzyme in the biosynthesis of BH4, an eNOS cofactor important for maintaining enzymatic coupling. We examined the associations betwee...

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Authors: Antoniades, C; Shirodaria, C; Van Assche, T; Cunnington, C; Tegeder, I

• Publication status: Published
• Journal: Journal of the American College of Cardiology
• Volume: 52
• Issue: 2
• Pages: 158-165
• Publication date: 2008-07-01
• DOI: 10.1016/j.jacc.2007.12.062
• EISSN: 1558-3597
• ISSN: 0735-1097
• Language: English
• Keywords: Biopterin; Genetic Variation; Mammary Arteries; Saphenous Vein; Aged; Female; Multivariate Analysis; Superoxides; Male; Haplotypes; Nitric Oxide; GTP Cyclohydrolase; Coronary Artery Disease; Humans; Endothelium, Vascular; Nitric Oxide Synthase Type III