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Journal article

Delayed treatment with AMPA, but not NMDA, antagonists reduces neocortical infarction.

Abstract:

We tested the abilities of two potent non-N-methyl-D-aspartate (non-NMDA) glutamate antagonists [2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(F)quinoxaline (NBQX)] and [1-(4-aminophenyl)-4-methyl-7,8-methylene-dioxy-5H-2,3-benzodiazep ine hydrochloride (GYKI 52466)] to reduce neocortical infarction following 2 h of transient middle cerebral artery occlusion in a hypertensive stroke model in the rat and compared these effects against, and in combination with, a potent NMDA antagonist [(+)-5-methyl-1...

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Publication status:
Published

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Publisher copy:
10.1038/jcbfm.1994.32

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Journal:
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Volume:
14
Issue:
2
Pages:
251-261
Publication date:
1994-03-05
DOI:
EISSN:
1559-7016
ISSN:
0271-678X
URN:
uuid:88570ed8-d1cd-40f7-bc47-e20cddaa5b3a
Source identifiers:
80177
Local pid:
pubs:80177

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