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Journal article

ChAdOx1 nCoV-19 protection against SARS-CoV-2 in rhesus macaque and ferret challenge models

Abstract:

Vaccines against SARS-CoV-2 are urgently required, but early development of vaccines against SARS-CoV-1 resulted in enhanced disease after vaccination. Careful assessment of this phenomena is warranted for vaccine development against SARS CoV-2. Here we report detailed immune profiling after ChAdOx1 nCoV-19 (AZD1222) and subsequent high dose challenge in two animal models of SARS-CoV-2 mediated disease. We demonstrate in rhesus macaques the lung pathology caused by SARS-CoV-2 mediated pneumon...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s42003-021-02443-0

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
ORCID:
0000-0001-7711-897X
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
ORCID:
0000-0001-7958-6961
More by this author
Role:
Author
ORCID:
0000-0002-0348-654X
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Publisher:
Springer Nature Publisher's website
Journal:
Communications Biology Journal website
Volume:
4
Issue:
1
Article number:
915
Publication date:
2021-07-26
Acceptance date:
2021-07-08
DOI:
EISSN:
2399-3642
Language:
English
Keywords:
Pubs id:
1187883
Local pid:
pubs:1187883
Deposit date:
2021-07-28

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