Journal article
The pathogen recognition sensor, NOD2, is variably expressed in patients with pulmonary tuberculosis
- Abstract:
-
Background NOD2, an intracellular pathogen recognition sensor, modulates innate defences to muropeptides derived from various bacterial species, including Mycobacterium tuberculosis (MTB). Experimentally, NOD2 attenuates two key putative mycobactericidal mechanisms. TNF-α synthesis is markedly reduced in MTB-antigen stimulated-mononuclear cells expressing mutant NOD2 proteins. NOD2 agonists also induce resistance to apoptosis, and may thus facilitate the surv...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Bibliographic Details
- Publisher:
- BioMed Central Publisher's website
- Journal:
- BMC Infectious Diseases Journal website
- Volume:
- 7
- Article number:
- 96
- Publication date:
- 2007-08-16
- Acceptance date:
- 2007-08-16
- DOI:
- EISSN:
-
1471-2334
Item Description
- Language:
- English
- Keywords:
- UUID:
-
uuid:8854017e-0bb8-4406-8378-d162bf866e7e
- Local pid:
- pubs:66470
- Source identifiers:
-
66470
- Deposit date:
- 2012-12-19
Terms of use
- Copyright holder:
- Lala et al
- Copyright date:
- 2007
- Notes:
- © 2007 Lala et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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