Journal article icon

Journal article

An expanded allosteric network in PTP1B by multitemperature crystallography, fragment screening, and covalent tethering

Abstract:

Allostery is an inherent feature of proteins, but it remains challenging to reveal the mechanisms by which allosteric signals propagate. A clearer understanding of this intrinsic circuitry would afford new opportunities to modulate protein function. Here, we have identified allosteric sites in protein tyrosine phosphatase 1B (PTP1B) by combining multiple-temperature X-ray crystallography experiments and structure determination from hundreds of individual small- molecule fragment soaks. New mo...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

Actions


Access Document


Files:
Publisher copy:
10.7554/eLife.36307.001

Authors


Expand authors...
A.P. Giannini Foundation More from this funder
Helen Hay Whitney Foundation More from this funder
Wellcome Trust More from this funder
Kinship Foundation More from this funder
Expand funders...
Publisher:
eLife Sciences Publications Publisher's website
Journal:
eLife Journal website
Volume:
7
Pages:
e36307
Publication date:
2018-06-07
Acceptance date:
2018-06-04
DOI:
EISSN:
2050-084X
Pubs id:
pubs:891906
URN:
uri:883b9c80-6cf1-414d-b385-27cec47e38c8
UUID:
uuid:883b9c80-6cf1-414d-b385-27cec47e38c8
Local pid:
pubs:891906

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP