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Energetics of ion permeation in an open-activated TRPV1 channel.

Abstract:

Ion channels enable diffusion of ions down physiological electrochemical gradients. Modulation of ion permeation is crucial for the physiological functioning of cells, and misregulation of ion channels is linked to a myriad of channelopathies. The ion permeation mechanism in the transient receptor potential (TRP) ion channel family is currently not understood at an atomistic level. In this work, we employed a simulation strategy for ion permeation (molecular-dynamics simulations with bias-exc...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.bpj.2016.08.009

Authors


Jorgensen, C More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Publisher:
Elsevier Publisher's website
Journal:
Biophysical Journal Journal website
Volume:
111
Issue:
6
Pages:
1214-1222
Publication date:
2016-09-05
Acceptance date:
2016-08-15
DOI:
EISSN:
1542-0086
ISSN:
0006-3495
Pubs id:
pubs:648055
URN:
uri:88315733-0732-474b-8ce9-e4f09344b8a1
UUID:
uuid:88315733-0732-474b-8ce9-e4f09344b8a1
Local pid:
pubs:648055

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