Journal article
Peroxynitrite activated drug conjugate systems based on a coumarin scaffold toward the application of theranostics
- Abstract:
-
Two novel drug-conjugates based on a “coumarin linker” have been designed for the synergic release of a therapeutic agent and fluorescent probe for the potential application of theranostics. The drug conjugates; CC-RNS and CI-RNS were designed to be activated by reactive oxygen species or reactive nitrogen species (ROS/RNS). The fluorescence OFF-ON response was triggered by the peroxynitrite-mediated transformation of a boronic acid pinacol ester to a phenol moiety with simultaneous release o...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Bibliographic Details
- Publisher:
- Frontiers Media Publisher's website
- Journal:
- Frontiers in Chemistry Journal website
- Volume:
- 7
- Article number:
- 775
- Publication date:
- 2019-12-05
- Acceptance date:
- 2019-10-25
- DOI:
- ISSN:
-
2296-2646
- Pmid:
-
31867305
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:1082182
- UUID:
-
uuid:882611d2-c7fb-4abc-928e-ee6fbfaccff4
- Local pid:
- pubs:1082182
- Source identifiers:
-
1082182
- Deposit date:
- 2020-01-16
Terms of use
- Copyright holder:
- Odyniec et al
- Copyright date:
- 2019
- Notes:
-
© 2019 Odyniec, Han, Gardiner, Sedgwick, He, Bull and James. This is an
open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
- Licence:
- CC Attribution (CC BY)
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