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Effect of vitamin A on bone resorption: evidence for direct stimulation of isolated chicken osteoclasts by retinol and retinoic acid.

Abstract:

The effects of retinol (vitamin A) and retinoic acid on primary cultures of isolated chicken osteoclasts have been studied. The experiments were performed to establish the direct actions of these two agents on the organization of cytoskeletal structures, on the acid phosphatase contents, and on the bone resorption activities of these cells. The results showed that by treating the cultures with retinol or retinoic acid, from 10(-8) to 10(-5) M, there were dose-related responses of the osteocla...

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Publication status:
Published

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Publisher copy:
10.1002/jbmr.5650030213

Authors


Oreffo, RO More by this author
Triffitt, JT More by this author
Francis, MJ More by this author
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Journal:
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Volume:
3
Issue:
2
Pages:
203-210
Publication date:
1988-04-05
DOI:
EISSN:
1523-4681
ISSN:
0884-0431
URN:
uuid:881d57d5-a788-4649-8aee-cdce7fb4eed2
Source identifiers:
108623
Local pid:
pubs:108623

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