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STEPWISE HYDROGEN REMOVAL IN THE ENZYMATIC RING EXPANSION OF PENICILLIN-N TO DEACETOXYCEPHALOSPORIN-C

Abstract:: Reaction of a 1:1 mixture of penicillin N and 2,2-bis(trideuteriomethyl) penicillin N with partially purified deacetoxy-cephalosporin C/deacetylcephalosporin C synthetase from Cephalosporium acremonium CO 728 resulted in preferential conversion of the protiated substrate, whereas in similar experiments with a 1:1 mixture of penicillin N and 3-deuteriopenicillin N both substrates were converted at the same rate; these results accord with a stepwise process for hydrogen removal during the ring ...
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Publication status:: Published

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APA Style

Baldwin, J., Adlington, R., Aplin, R., Crouch, N., Schofield, C., & Ting, H. (1987). STEPWISE HYDROGEN REMOVAL IN THE ENZYMATIC RING EXPANSION OF PENICILLIN-N TO DEACETOXYCEPHALOSPORIN-C. JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 21, 1654–1656.

MLA Style

Baldwin, J., et al. “STEPWISE HYDROGEN REMOVAL IN THE ENZYMATIC RING EXPANSION OF PENICILLIN-N TO DEACETOXYCEPHALOSPORIN-C.” JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, no. 21, 1987, pp. 1654–56.

Chicago Style

Baldwin, J, R Adlington, R Aplin, N Crouch, C Schofield, and H Ting. 1987. “STEPWISE HYDROGEN REMOVAL IN THE ENZYMATIC RING EXPANSION OF PENICILLIN-N TO DEACETOXYCEPHALOSPORIN-C.” JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, no. 21: 1654–56.
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Publisher copy:: 10.1039/c39870001654

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+ Baldwin, J More by this author

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+ Adlington, R More by this author

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+ Aplin, R More by this author

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+ Crouch, N More by this author

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+ Schofield, C More by this author

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Bibliographic Details

Journal:: JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS
Issue:: 21
Pages:: 1654-1656
Publication date:: 1987-11-01
DOI:: 10.1039/c39870001654
ISSN:: 0022-4936

Item Description

Language:: English
Pubs id:: pubs:42834
UUID:: uuid:881c773b-1311-40b5-865c-e280dce6029f
Local pid:: pubs:42834
Source identifiers:: 42834
Deposit date:: 2012-12-19

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Copyright date:: 1987

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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