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Na/K pump regulation of cardiac repolarization: Insights from a systems biology approach

Abstract:

The sodium-potassium pump is widely recognized as the principal mechanism for active ion transport across the cellular membrane of cardiac tissue, being responsible for the creation and maintenance of the transarcolemmal sodium and potassium gradients, crucial for cardiac cell electrophysiology. Importantly, sodium-potassium pump activity is impaired in a number of major diseased conditions, including ischemia and heart failure. However, its subtle ways of action on cardiac electrophysiology,...

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Publication date:
2013-01-01
URN:
uuid:88177bdc-404e-4981-aa20-ad4f22dd582b
Local pid:
oai:eprints.maths.ox.ac.uk:1721

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