Journal article icon

Journal article

ASYMMETRIC-SYNTHESIS OF ANTI-ALPHA-ALKYL-BETA-AMINO CARBOXAMIDES

Abstract:

The alkylation reactions of enolates derived from the highly diastereoselective conjugate additions of lithium (R)-N-benzyl-N-α-methylbenzylamide (R)-1 to N,N-dimethyl crotonamide 2 and N,N-dimethyl cinnamide 3 have been investigated. The alkylations of enolates derived from 3 are shown to afford anti-α-alkyl-β-amino carboxamides with excellent stereocontrol: the stereochemistry is assigned with the aid of a single crystal X-ray structure of (2R,3S,αR)-N,N-dimethyl 2-benzyl-3-phenyl-3-(N-benz...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1002/recl.19951140409

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Role:
Author
Journal:
RECUEIL DES TRAVAUX CHIMIQUES DES PAYS-BAS-JOURNAL OF THE ROYAL NETHERLANDS CHEMICAL SOCIETY
Volume:
114
Issue:
4-5
Pages:
175-183
Publication date:
1995-01-01
DOI:
ISSN:
0165-0513
URN:
uuid:880d88c9-81ff-40ae-93ba-f177c7f3169c
Source identifiers:
168595
Local pid:
pubs:168595

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP