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Functional Changes in the Language Network in Response to Increased Amyloid β Deposition in Cognitively Intact Older Adults.

Abstract:

Word finding symptoms are frequent early in the course of Alzheimer's disease and relate principally to functional changes in left posterior temporal cortex. In cognitively intact older adults, we examined whether amyloid load affects the network for language and associative-semantic processing. Fifty-six community-recruited subjects (52-74 years), stratified for apolipoprotein E and brain-derived neurotrophic factor genotype, received a neurolinguistic assessment, (18)F-flutemetamol positron...

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Publisher copy:
10.1093/cercor/bhu286

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Institution:
University of Oxford
Department:
Oxford, MSD, Experimental Psychology
Role:
Author
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Journal:
Cerebral cortex (New York, N.Y. : 1991)
Publication date:
2014-12-05
DOI:
EISSN:
1460-2199
ISSN:
1047-3211
URN:
uuid:8805c7f5-39b9-4e1d-97f5-ef98a3861358
Source identifiers:
492111
Local pid:
pubs:492111
Language:
English
Keywords:

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