Journal article icon

Journal article

Synthesis of 1-methyl-2-diphenylphosphino-3-(1'-isoquinolyl)indole; An easily racemised ligand giving insights into catalytic asymmetric allylation

Abstract:

The synthesis of the title compound is described, involving 2-lithiation and phosphinylation of the coupled heterocycle in the final step. Attempts to resolve the phosphine by previously described methods led to its immediate racemisation, also observed more slowly in the PdCl2 complex, for which the X-ray structure is described. The phosphinamine formed a cationic pd(1,3-diphenylallyl) complex with high diastereoselectivity. By analysis of the solution stucture using NMR techniques, in compa...

Expand abstract
Publication status:
Published

Actions


Access Document


Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Role:
Author
Journal:
TETRAHEDRON
Volume:
53
Issue:
11
Pages:
4035-4050
Publication date:
1997-03-17
DOI:
ISSN:
0040-4020
URN:
uuid:8801d692-cce9-4134-8399-e8b0b64211da
Source identifiers:
60034
Local pid:
pubs:60034

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP