Crystal structure and binding properties of the CD2 and CD244 (2B4)-binding protein, CD48.

Journal article

The structural analysis of surface proteins belonging to the CD2 subset of the immunoglobulin superfamily has yielded important insights into transient cellular interactions. In mice and rats, CD2 and CD244 (2B4), which are expressed predominantly on T cells and natural killer cells, respectively, bind the same, broadly expressed ligand, CD48. Structures of CD2 and CD244 have been solved previously, and we now present the structure of the receptor-binding domain of rat CD48. The receptor-bind...

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Authors: Evans, E; Castro, M; O'Brien, R; Kearney, A; Walsh, H

• Publication status: Published
• Journal: Journal of biological chemistry
• Volume: 281
• Issue: 39
• Pages: 29309-29320
• Publication date: 2006-09-01
• DOI: 10.1074/jbc.m601314200
• EISSN: 1083-351X
• ISSN: 0021-9258
• Language: English
• Keywords: Ligands; Evolution, Molecular; Models, Molecular; Protein Conformation; Humans; Receptors, Immunologic; Rats; Antigens, CD2; Antigens, CD58; Protein Structure, Tertiary; Thermodynamics; Animals; Antigens, CD; Membrane Glycoproteins; Protein Binding