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Selection on non-antigenic gene segments of seasonal influenza A virus and its impact on adaptive evolution

Abstract:

Most studies on seasonal influenza A/H3N2 virus adaptation have focused on the main antigenic gene, hemagglutinin. However, there is increasing evidence that the genome-wide genetic background of novel antigenic variants can influence these variants' emergence probabilities and impact their patterns of dominance in the population. This suggests that non-antigenic genes may be important in shaping the viral evolutionary dynamics. To better understand the role of selection on non-antigenic gene...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1093/ve/vex034

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More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Zoology
ORCID:
0000-0001-8538-4995
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Mathematical Institute
Oxford college:
Christ Church
Publisher:
Oxford University Press Publisher's website
Journal:
Virus Evolution Journal website
Volume:
3
Issue:
2
Pages:
034
Publication date:
2017-11-09
Acceptance date:
2017-10-13
DOI:
EISSN:
2057-1577
Pubs id:
pubs:812985
URN:
uri:87fa27ec-e46e-4ca4-8654-8f4b8c3b894a
UUID:
uuid:87fa27ec-e46e-4ca4-8654-8f4b8c3b894a
Local pid:
pubs:812985

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