EMR1, the human homolog of F4/80, is an eosinophil-specific receptor.

Journal article

The EGF-TM7 F4/80 is a defining marker of murine macrophage populations. Applying flow cytometric analysis using the newly generated mAb A10, and quantitative real-time PCR, we here report the surprising observation that the human ortholog of F4/80, EGF-like module containing mucin-like hormone receptor (EMR)1, is absent on mononuclear phagocytic cells including monocytes, macrophages, and myeloid dendritic cells. Unexpectedly, we found that EMR1 expression is restricted to eosinophilic granu...

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Authors: Hamann, J; Koning, N; Pouwels, W; Ulfman, L; van Eijk, M

• Publication status: Published
• Journal: European journal of immunology
• Volume: 37
• Issue: 10
• Pages: 2797-2802
• Publication date: 2007-10-01
• DOI: 10.1002/eji.200737553
• EISSN: 1521-4141
• ISSN: 0014-2980
• Language: English
• Keywords: CHO Cells; Biological Markers; Mucins; Cells, Cultured; Saguinus; Papio; Eosinophils; Structural Homology, Protein; Humans; Membrane Glycoproteins; Mice; Receptors, G-Protein-Coupled; Cricetinae; Antigens, Differentiation; Animals; Antibodies, Monoclonal; Macaca mulatta; Pongo pygmaeus; Cricetulus; Pan troglodytes