Exhaustive differentiation of alloreactive CD8+ T cells: critical for determination of graft acceptance or rejection.

Journal article

BACKGROUND: The precise role that CD8+ T cells play in the rejection and acceptance of different types of allograft is unclear and has been shown to vary between donor-recipient combinations. METHODS: The response of adoptively transferred CD8+ T cells reactive to the donor alloantigen H2Kb was examined after transplantation of H2Kb liver, kidney, and heart grafts in mice. RESULTS: After transfer of 6 x 10(6) alloreactive CD8+ T cells to T-cell depleted syngeneic mice spontaneous long-term a...

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Authors: Steger, U; Denecke, C; Sawitzki, B; Karim, M; Jones, N

• Publication status: Published
• Journal: Transplantation
• Volume: 85
• Issue: 9
• Pages: 1339-1347
• Publication date: 2008-05-01
• DOI: 10.1097/tp.0b013e31816dd64a
• EISSN: 1534-6080
• ISSN: 0041-1337
• Language: English
• Keywords: Transplantation, Isogeneic; Cell Differentiation; CD8-Positive T-Lymphocytes; Mice, Inbred C57BL; Liver Transplantation; Mice, Inbred CBA; Kidney Transplantation; Mice; Graft Survival; Transplantation, Homologous; Models, Animal; Lymphocyte Transfusion; Animals; Graft Rejection