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Efficacy of RTS,S/AS01E malaria vaccine and exploratory analysis on anti-circumsporozoite antibody titres and protection in children aged 5-17 months in Kenya and Tanzania: a randomised controlled trial.

Abstract:

BACKGROUND: RTS,S/AS01E is the lead candidate malaria vaccine. We recently showed efficacy against clinical falciparum malaria in 5-17 month old children, during an average of 8 months follow-up. We aimed to assess the efficacy of RTS,S/AS01E during 15 months of follow-up. METHODS: Between March, 2007, and October, 2008, we enrolled healthy children aged 5-17 months in Kilifi, Kenya, and Korogwe, Tanzania. Computer-generated block randomisation was used to randomly assign participants (1:1) t...

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Authors


Lusingu, J More by this author
Lievens, M More by this author
Vekemans, J More by this author
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Journal:
The Lancet. Infectious diseases
Volume:
11
Issue:
2
Pages:
102-109
Publication date:
2011-02-05
DOI:
EISSN:
1474-4457
ISSN:
1473-3099
URN:
uuid:87debe42-3b52-489f-a973-866baf7234a4
Source identifiers:
115910
Local pid:
pubs:115910

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