Efficacy of RTS,S/AS01E malaria vaccine and exploratory analysis on anti-circumsporozoite antibody titres and protection in children aged 5-17 months in Kenya and Tanzania: a randomised controlled trial.

Olotu, A; Lusingu, J; Leach, A; Lievens, M; Vekemans, J; Msham, S; Lang, T; Gould, J; Dubois, MC; Jongert, E; Vansadia, P; Carter, T; Njuguna, P; Awuondo, KO; Malabeja, A; Abdul, O; Gesase, S; Mturi, N; Drakeley, CJ; Savarese, B; Villafana, T; Lapierre, D; Ballou, WR; Cohen, J; Lemnge, MM; Peshu, N; Marsh, K; Riley, EM; von Seidlein, L; Bejon, P

Abstract:

BACKGROUND: RTS,S/AS01E is the lead candidate malaria vaccine. We recently showed efficacy against clinical falciparum malaria in 5-17 month old children, during an average of 8 months follow-up. We aimed to assess the efficacy of RTS,S/AS01E during 15 months of follow-up. METHODS: Between March, 2007, and October, 2008, we enrolled healthy children aged 5-17 months in Kilifi, Kenya, and Korogwe, Tanzania. Computer-generated block randomisation was used to randomly assign participants (1:1) t...

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APA Style

Olotu, A., Lusingu, J., Leach, A., Lievens, M., Vekemans, J., Msham, S., Lang, T., Gould, J., Dubois, M. C., Jongert, E., Vansadia, P., Carter, T., Njuguna, P., Awuondo, K. O., Malabeja, A., Abdul, O., Gesase, S., Mturi, N., Drakeley, C. J., … Bejon, P. (2011). Efficacy of RTS,S/AS01E malaria vaccine and exploratory analysis on anti-circumsporozoite antibody titres and protection in children aged 5-17 months in Kenya and Tanzania: a randomised controlled trial. The Lancet. Infectious Diseases, 11(2), 102–109.

MLA Style

Olotu, A., et al. “Efficacy of RTS,S/AS01E Malaria Vaccine and Exploratory Analysis on Anti-Circumsporozoite Antibody Titres and Protection in Children Aged 5-17 Months in Kenya and Tanzania: a Randomised Controlled Trial.” The Lancet. Infectious Diseases, vol. 11, no. 2, The Lancet. Infectious diseases, 2011, pp. 102–09.

Chicago Style

Olotu, A, J Lusingu, A Leach, M Lievens, J Vekemans, S Msham, T Lang, et al. 2011. “Efficacy of RTS,S/AS01E Malaria Vaccine and Exploratory Analysis on Anti-Circumsporozoite Antibody Titres and Protection in Children Aged 5-17 Months in Kenya and Tanzania: a Randomised Controlled Trial.” The Lancet. Infectious Diseases 11 (2): 102–9.
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