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Niche and local geography shape the pangenome of wastewater- and livestock-associated Enterobacteriaceae.

Abstract:

Escherichia coli and other Enterobacteriaceae are diverse species with “open” pangenomes, where genes move intra- and interspecies via horizontal gene transfer. However, most analyses focus on clinical isolates. The pangenome dynamics of natural populations remain understudied, despite their suggested role as reservoirs for antimicrobial resistance (AMR) genes. Here, we analyze near-complete genomes for 827 Enterobacteriaceae (553 Escherichia and 274 non-Escherichia spp.) with 2292 circulariz...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1126/sciadv.abe3868

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Zoology
Role:
Author
ORCID:
0000-0001-7332-0820
More by this author
Role:
Author
ORCID:
0000-0002-6926-080X
More by this author
Role:
Author
ORCID:
0000-0003-1495-0843
More by this author
Role:
Author
ORCID:
0000-0003-4190-1473
More by this author
Role:
Author
ORCID:
0000-0002-5527-1209
Publisher:
American Association for the Advancement of Science Publisher's website
Journal:
Science Advances Journal website
Volume:
7
Issue:
15
Article number:
eabe3868
Publication date:
2021-04-09
Acceptance date:
2021-02-22
DOI:
EISSN:
2375-2548
Pmid:
33837077
Language:
English
Keywords:
Pubs id:
1170950
Local pid:
pubs:1170950
Deposit date:
2021-04-27

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