Induction of cytotoxic T lymphocyte (CTL) responses against minor histocompatibility antigens is dependent upon the presence of T cell help and requires the interaction of CD40 on dendritic cells (DCs) with CD40 ligand on activated T helper cells (Th). This study demonstrates that CD40 is neither involved in Th-dependent nor Th-independent antiviral CTL responses. Moreover, the data show that DC maturation occurs in vivo after viral infection in the absence of CD40 and Th. This maturation did...Expand abstract
- Publication status:
- Publisher copy:
- Copyright date:
CD8(+) T cells mediate CD40-independent maturation of dendritic cells in vivo.
Views and Downloads
If you are the owner of this record, you can report an update to it here: Report update to this record