Journal article icon

Journal article

Hypothyroidism in utero stimulates pancreatic beta cell proliferation and hyperinsulinaemia in the ovine fetus during late gestation

Abstract:

Development of pancreatic beta cell mass before birth is essential for normal growth of the fetus and for long-term control of carbohydrate metabolism in postnatal life. Thyroid hormones are also important regulators of fetal growth, and the present study tested the hypotheses that thyroid hormones promote beta cell proliferation in the fetal ovine pancreatic islets, and that growth retardation in hypothyroid fetal sheep is associated with reductions in pancreatic beta cell mass and circulati...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

Actions


Access Document


Files:
Publisher copy:
10.1113/JP273555

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, Department of Physiology Anatomy and Genetics
De Blasio, MJ More by this author
Davenport, HM More by this author
Expand authors...
More from this funder
Funding agency for:
Harris, SE
Publisher:
Wiley Publisher's website
Journal:
Journal of Physiology Journal website
Volume:
595
Issue:
11
Pages:
3331–3343
Publication date:
2017-01-31
Acceptance date:
2017-01-11
DOI:
ISSN:
0022-3751 and 1469-7793
Pubs id:
pubs:675924
URN:
uri:87ca33f0-0607-47e0-b787-22451b472a29
UUID:
uuid:87ca33f0-0607-47e0-b787-22451b472a29
Local pid:
pubs:675924

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP