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ErbB-2 blockade and prenyltransferase inhibition alter epidermal growth factor and epidermal growth factor receptor trafficking and enhance (111)In-DTPA-hEGF Auger electron radiation therapy.

Abstract:

The intracellular distribution of Auger electron-emitting radiopharmaceuticals is a determinant of cytotoxicity. However, the mechanisms by which these agents are routed through the cell are ill understood. The aim of this study was to investigate how trafficking of (111)In-labeled human epidermal growth factor ((111)In-DTPA-hEGF) relates to that of the EGF receptor (EGFR) and whether coadministration of agents that modulate EGFR signaling alters the efficacy of (111)In-DTPA-hEGF.The spatiote...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.2967/jnumed.110.084392

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford
Role:
Author
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Cancer Research UK More from this funder
Medical Research Council More from this funder
CRUK/EPSRC Oxford Cancer Imaging Centre More from this funder
National Institute for Health Research Oxford Biomedical Research Centre More from this funder
Publisher:
Society of Nuclear Medicine Publisher's website
Journal:
Journal of nuclear medicine : official publication, Society of Nuclear Medicine Journal website
Volume:
52
Issue:
5
Pages:
776-783
Publication date:
2011-01-01
DOI:
EISSN:
1535-5667
ISSN:
0161-5505
URN:
uuid:87c1b803-5a1a-4028-9303-1452aa39e9b9
Source identifiers:
134951
Local pid:
pubs:134951

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