Journal article
ErbB-2 blockade and prenyltransferase inhibition alter epidermal growth factor and epidermal growth factor receptor trafficking and enhance (111)In-DTPA-hEGF Auger electron radiation therapy.
- Abstract:
-
The intracellular distribution of Auger electron-emitting radiopharmaceuticals is a determinant of cytotoxicity. However, the mechanisms by which these agents are routed through the cell are ill understood. The aim of this study was to investigate how trafficking of (111)In-labeled human epidermal growth factor ((111)In-DTPA-hEGF) relates to that of the EGF receptor (EGFR) and whether coadministration of agents that modulate EGFR signaling alters the efficacy of (111)In-DTPA-hEGF.The spatiote...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Publisher copy:
- 10.2967/jnumed.110.084392
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Authors
Funding
National Institute for Health Research Oxford Biomedical
Research Centre
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CRUK/EPSRC Oxford Cancer Imaging Centre
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Cancer Research
UK
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Medical Research Council
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Bibliographic Details
- Publisher:
- Society of Nuclear Medicine Publisher's website
- Journal:
- Journal of nuclear medicine : official publication, Society of Nuclear Medicine Journal website
- Volume:
- 52
- Issue:
- 5
- Pages:
- 776-783
- Publication date:
- 2011-01-01
- DOI:
- EISSN:
-
1535-5667
- ISSN:
-
0161-5505
- Source identifiers:
-
134951
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:134951
- UUID:
-
uuid:87c1b803-5a1a-4028-9303-1452aa39e9b9
- Local pid:
- pubs:134951
- Deposit date:
- 2012-12-19
Terms of use
- Copyright holder:
- Society of Nuclear Medicine
- Copyright date:
- 2011
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