ErbB-2 blockade and prenyltransferase inhibition alter epidermal growth factor and epidermal growth factor receptor trafficking and enhance (111)In-DTPA-hEGF Auger electron radiation therapy.

Journal article

The intracellular distribution of Auger electron-emitting radiopharmaceuticals is a determinant of cytotoxicity. However, the mechanisms by which these agents are routed through the cell are ill understood. The aim of this study was to investigate how trafficking of (111)In-labeled human epidermal growth factor ((111)In-DTPA-hEGF) relates to that of the EGF receptor (EGFR) and whether coadministration of agents that modulate EGFR signaling alters the efficacy of (111)In-DTPA-hEGF.The spatiote...

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Authors: Cornelissen, B; Darbar, S; Hernandez, R; Kersemans, V; Tullis, I

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Society of Nuclear Medicine Publisher's website
• Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine Journal website
• Volume: 52
• Issue: 5
• Pages: 776-783
• Publication date: 2011-01-01
• DOI: 10.2967/jnumed.110.084392
• EISSN: 1535-5667
• ISSN: 0161-5505
• Language: English
• Keywords: Signal Transduction; Colony-Forming Units Assay; Antibodies, Monoclonal; Protein Transport; Mice; Epidermal Growth Factor; Antibodies, Monoclonal, Humanized; Cell Line, Tumor; Pentetic Acid; Receptor, Epidermal Growth Factor; Animals; Dimethylallyltranstransferase; Receptor, erbB-2; Active Transport, Cell Nucleus; Cell Nucleus; Humans; Imidazoles; Cell Proliferation; Electrons; Female; Protein Kinase Inhibitors