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Thesis

Investigating enteric fever – application of controlled human infection models to understand enteric fever pathogenesis and immunity

Abstract:

The development of novel vaccines for typhoidal Salmonella is hampered, in part, by a limited understanding of protective host immune responses to infection, the absence of reliable immunological correlates of protection, and uncertainties relating to disease pathogenesis. Controlled human infection models (CHIM) for Salmonella Typhi and Paratyphi have recently been re-established. In this thesis, I describe the application of two controlled human infection studies (CHIM)...

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Division:
MSD
Department:
Paediatrics
Role:
Author

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Role:
Supervisor
Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
UUID:
uuid:87bcba73-64fb-4df9-8ee5-fb0eed6e75f8
Deposit date:
2020-01-30

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