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Macrophages in obesity

Abstract:

Obesity is a worldwide public health concern yet no safe therapies are currently available. The activity of sympathetic neurons is necessary and sufficient for fat mass reduction, via norepinephrine (NE) signaling. Macrophage accumulation in the adipose tissue is thought to play the central role in the onset of obesity, yet their relation to NE has been controversial. We have identified a population of sympathetic neuron-associated macrophages (SAMs) that control obesity via the uptake and cl...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1016/j.cellimm.2018.04.014

Authors


Pirzgalska, RM More by this author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
Oxford college:
Lady Margaret Hall
ORCID:
0000-0002-7938-4814
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Funding agency for:
Pirzgalska, RM
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Grant:
FCT_BIM-MET-3750-2014
Publisher:
Elsevier Publisher's website
Journal:
Cellular Immunology Journal website
Volume:
330
Pages:
183-187
Publication date:
2018-05-03
Acceptance date:
2018-04-26
DOI:
EISSN:
1090-2163
ISSN:
0008-8749
Pubs id:
pubs:897012
URN:
uri:87b94e68-1c30-490b-b0a7-449b14363ee8
UUID:
uuid:87b94e68-1c30-490b-b0a7-449b14363ee8
Local pid:
pubs:897012

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