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Differentiated baroreflex modulation of sympathetic nerve activity during deep brain stimulation in humans

Abstract:

Targeted electric deep brain stimulation in midbrain nuclei in humans alters cardiovascular parameters, presumably by modulating autonomic and baroreflex function. Baroreflex modulation of sympathetic outflow is crucial for cardiovascular regulation and is hypothesized to occur at 2 distinct brain locations. The aim of this study was to evaluate sympathetic outflow in humans with deep brain stimulating electrodes during ON and OFF stimulation of specific midbrain nuclei known to regulate card...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Surgical Sciences
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Surgical Sciences
Oxford college:
St Antonys College
ORCID:
0000-0002-7262-7297
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Surgical Sciences
Oxford college:
Exeter, Exeter College
Bahuri, NFA More by this author
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Publisher:
American Heart Association Publisher's website
Journal:
Hypertension Journal website
Volume:
63
Issue:
05
Pages:
1000–1010
Publication date:
2014-05-01
Acceptance date:
2014-01-14
DOI:
EISSN:
1524-4563
ISSN:
0194-911X
Pubs id:
pubs:471736
URN:
uri:87b843bf-e138-4c9d-916a-6a0f762dd143
UUID:
uuid:87b843bf-e138-4c9d-916a-6a0f762dd143
Local pid:
pubs:471736

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