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Journal article

Regulation of major histocompatibility complex class II gene expression, genetic variation and disease.

Abstract:

Major histocompatibility complex (MHC) class II molecules are central to adaptive immune responses and maintenance of self-tolerance. Since the early 1970s, the MHC class II region at chromosome 6p21 has been shown to be associated with a remarkable number of autoimmune, inflammatory and infectious diseases. Given that a full explanation for most MHC class II disease associations has not been reached through analysis of structural variation alone, in this review we examine the role of genetic...

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Publication status:
Published

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Publisher copy:
10.1038/gene.2009.83

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
Journal:
Genes and immunity
Volume:
11
Issue:
2
Pages:
99-112
Publication date:
2010-03-01
DOI:
EISSN:
1476-5470
ISSN:
1466-4879
Source identifiers:
7919
Language:
English
Keywords:
Pubs id:
pubs:7919
UUID:
uuid:87b7c09e-0d1c-40ed-99b5-0f609a6935d7
Local pid:
pubs:7919
Deposit date:
2012-12-19

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