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Three-dimensional solution structure of the extracellular region of the complement regulatory protein CD59, a new cell-surface protein domain related to snake venom neurotoxins.

Abstract:

The cell surface antigen CD59 is an inhibitor of complement-mediated lysis and a member of the Ly6 superfamily (Ly6SF) of cysteine-rich cell-surface molecules whose sequences are related to those of snake venom neurotoxins. The three-dimensional solution structure of a recombinant form of the extracellular region of the molecule (residues 1-70 of the mature protein; sCD59) has been solved by 2D NMR methods. sCD59 is a relatively flat, disk-shaped molecule consisting of a two-standed beta-shee...

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Publication status:
Published

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Publisher copy:
10.1021/bi00181a006

Authors


Kieffer, B More by this author
Driscoll, PC More by this author
Campbell, ID More by this author
Willis, AC More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
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Journal:
Biochemistry
Volume:
33
Issue:
15
Pages:
4471-4482
Publication date:
1994-04-05
DOI:
EISSN:
1520-4995
ISSN:
0006-2960
URN:
uuid:87ac9a58-b0e0-4ccf-b292-c222057948e9
Source identifiers:
10843
Local pid:
pubs:10843

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