Interleukin-10 promoter polymorphisms and the outcome of hepatitis C virus infection.

Journal article

The natural outcome and response to treatment in hepatitis C virus (HCV) infection varies between individuals. Whereas some variation may be attributable to viral and environmental variables, it is probable that host genetic background also plays a significant role. Interleukin (IL)-10 has a key function in the regulation of cellular immune responses and in the suppression of pro-inflammatory cytokine secretion. Functional polymorphisms in the IL-10 gene have been described. We investigated t...

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Authors: Knapp, S; Hennig, B; Frodsham, A; Zhang, L; Hellier, S

• Publication status: Published
• Journal: Immunogenetics
• Volume: 55
• Issue: 6
• Pages: 362-369
• Publication date: 2003-09-01
• DOI: 10.1007/s00251-003-0594-5
• EISSN: 1432-1211
• ISSN: 0093-7711
• Language: English
• Keywords: Humans; Treatment Outcome; Fibrosis; Promoter Regions, Genetic; Polymorphism, Genetic; Female; Interleukin-10; Disease Progression; Male; Hepatitis C; Haplotypes