Journal article icon

Journal article

The Msb3/Gyp3 GAP controls the activity of the Rab GTPases Vps21 and Ypt7 at endosomes and vacuoles.

Abstract:

Fusion of organelles in the endomembrane system depends on Rab GTPases that interact with tethering factors before lipid bilayer mixing. In yeast, the Rab5 GTPase Vps21 controls fusion and membrane dynamics between early and late endosomes. Here we identify Msb3/Gyp3 as a specific Vps21 GTPase-activating protein (GAP). Loss of Msb3 results in an accumulation of Vps21 and one of its effectors Vps8, a subunit of the CORVET complex, at the vacuole membrane in vivo. In agreement, Msb3 forms a spe...

Expand abstract

Actions


Access Document


Publisher copy:
10.1091/mbc.e11-12-1030

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
Journal:
Molecular biology of the cell
Volume:
23
Issue:
13
Pages:
2516-2526
Publication date:
2012-07-01
DOI:
EISSN:
1939-4586
ISSN:
1059-1524
Source identifiers:
332935

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP