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PET imaging of DNA damage using 89Zr-labelled anti-γH2AX-TAT immunoconjugates

Abstract:

© 2015, Springer-Verlag Berlin Heidelberg. Purpose: The efficacy of most anticancer treatments, including radiotherapy, depends on an ability to cause DNA double-strand breaks (DSBs). Very early during the DNA damage signalling process, the histone isoform H2AX is phosphorylated to form γH2AX. With the aim of positron emission tomography (PET) imaging of DSBs, we synthesized a 89Zr-labelled anti-γH2AX antibody, modified with the cell-penetrating peptide, TAT, which includes a nucle...

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Publisher copy:
10.1007/s00259-015-3092-8

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Journal:
European Journal of Nuclear Medicine and Molecular Imaging
Volume:
42
Issue:
11
Pages:
1707-1717
Publication date:
2015-06-02
DOI:
EISSN:
1619-7089
ISSN:
1619-7070
Source identifiers:
545551
Pubs id:
pubs:545551
UUID:
uuid:878af68a-3770-41ac-af64-9eb13599f7b1
Local pid:
pubs:545551
Deposit date:
2015-11-19

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