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A theoretical investigation of the effect of proliferation and adhesion on monoclonal conversion in the colonic crypt

Abstract:

The surface epithelium lining the intestinal tract renews itself rapidly by a coordinated programme of cell proliferation, migration and differentiation events that is initiated in the crypts of Lieberkuhn. It is generally believed that colorectal cancer arises due to mutations that disrupt the normal cellular dynamics of the crypts. Using a spatially structured cell-based model of a colonic crypt, we investigate the likelihood that the progeny of a mutated cell will dominate, or be sloughed ...

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Publisher copy:
10.1016/j.jtbi.2012.08.002

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Journal:
Journal of Theoretical Biology
Volume:
312
Issue:
7
Pages:
143-156
Publication date:
2012-01-01
DOI:
URN:
uuid:87895c4e-db1d-4083-99ac-fab99537538a
Local pid:
cs:6210

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