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Plasmodium falciparum-infected erythrocytes: agglutination by diverse Kenyan plasma is associated with severe disease and young host age.

Abstract:

The variant surface antigens (VSAs) of Plasmodium falciparum-infected red blood cells are potentially important targets of naturally acquired immunity to malaria. Natural infections induce agglutinating antibodies specific to the VSA variants expressed by the infecting parasites. Previously, when different parasite isolates were tested against a panel of heterologous plasma from Kenyan children, the proportion of plasma that agglutinated the parasites (the agglutination frequency [AF]) was hi...

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Publication status:
Published

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Publisher copy:
10.1086/315652

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
Journal:
Journal of infectious diseases
Volume:
182
Issue:
1
Pages:
252-259
Publication date:
2000-07-01
Event title:
11th British Parasitology Meeting of the Imperial-College-of-Science, Technology, and Medicine
DOI:
EISSN:
1537-6613
ISSN:
0022-1899
Keywords:
Pubs id:
pubs:30815
UUID:
uuid:87866c60-903d-44d1-8bae-fc39e020902f
Local pid:
pubs:30815
Source identifiers:
30815
Deposit date:
2012-12-19

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