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Clinical impairment in premanifest and early Huntington's disease is associated with regionally specific atrophy

Abstract:

TRACK-HD is a multicentre longitudinal observational study investigating the use of clinical assessments and 3-Tesla magnetic resonance imaging as potential biomarkers for future therapeutic trials in Huntington's disease (HD). The cross-sectional data from this large well-characterized dataset provide the opportunity to improve our knowledge of how the underlying neuropathology of HD may contribute to the clinical manifestations of the disease across the spectrum of premanifest (PreHD) and e...

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Publisher copy:
10.1002/hbm.21449

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Journal:
Human Brain Mapping
Volume:
34
Issue:
3
Pages:
519-529
Publication date:
2013-03-05
DOI:
EISSN:
1097-0193
ISSN:
1065-9471
URN:
uuid:87828adf-212c-4e0f-bef7-45c994d08c9a
Source identifiers:
384750
Local pid:
pubs:384750

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