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Neutralizing antibodies against Plasmodium falciparum associated with successful cure after drug therapy

Abstract:

An effective antibody response can assist drug treatment to contribute to better parasite clearance in malaria patients. To examine this, sera were obtained from two groups of adult patients with acute falciparum malaria, prior to drug treatment: patients who (1) have subsequent recrudescent infection, or (2) were cured by Day 28 following treatment. Using a Plasmodium falciparum antigen library, we examined the antibody specificities in these sera. While the antibody repertoire of both sera ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pone.0159347

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Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Tropical Medicine
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Tropical Medicine
Singapore’s Agency for Science, Technology and Research More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS One Journal website
Volume:
11
Issue:
7
Pages:
e0159347
Publication date:
2016-07-18
DOI:
ISSN:
1932-6203
URN:
uuid:877bc9a1-fa8e-4104-a486-68c2b80c196e
Source identifiers:
633439
Local pid:
info:fedora/pubs:633439

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