Journal article
Identity-by-descent detection across 487,409 British samples reveals fine-scale population structure, evolutionary history, and trait associations
- Abstract:
-
Detection of Identical-By-Descent (IBD) segments provides a fundamental measure of genetic relatedness and plays a key role in a wide range of analyses. We develop FastSMC, an IBD detection algorithm that combines a fast heuristic search with accurate coalescent-based likelihood calculations. FastSMC enables biobank-scale detection and dating of IBD segments within several thousands of years in the past. We apply FastSMC to 487,409 UK Biobank samples and detect ~214 billion IBD segments trans...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Bibliographic Details
- Publisher:
- Springer Nature Publisher's website
- Journal:
- Nature Communications Journal website
- Volume:
- 11
- Article number:
- 6130
- Publication date:
- 2020-11-30
- Acceptance date:
- 2020-10-02
- DOI:
- EISSN:
-
2041-1723
- ISSN:
-
2041-1723
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
1128980
- Local pid:
- pubs:1128980
- Deposit date:
- 2020-08-28
Terms of use
- Copyright holder:
- Nait Saada et al.
- Copyright date:
- 2020
- Rights statement:
- © The Author(s) 2020. Open Access: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.
- Licence:
- CC Attribution (CC BY)
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