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The impact of an extended nucleobase-2′-deoxyribose linker in the biophysical and biological properties of oligonucleotides

Abstract:

Interest in artificial DNA mimetics has been triggered by the widespread applications of nucleic acids as they are useful tools for modulation of the biophysical and biological properties of oligonucleotides. In this article, we describe the synthesis and properties of a novel thymine derivative (T*) containing an extended linker between the thymine nucleobase and the 2′-deoxyribose moiety. The modified 2′-deoxyribosyl derivative was prepared via coupling of a functionalized nucleobase to the...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1039/C6RA26852H

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Role:
Author
ORCID:
0000-0002-2883-5267
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Role:
Author
ORCID:
0000-0002-7732-4543
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
Role:
Author
ORCID:
0000-0001-6421-7733
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Role:
Author
ORCID:
0000-0003-3047-738X
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Publisher:
Royal Society of Chemistry Publisher's website
Journal:
RSC Advances Journal website
Volume:
7
Issue:
16
Pages:
9579-9586
Publication date:
2017-01-31
Acceptance date:
2017-01-27
DOI:
ISSN:
2046-2069
Pubs id:
pubs:745464
URN:
uri:8779e627-f1ee-4ab8-8b23-015eec0759a4
UUID:
uuid:8779e627-f1ee-4ab8-8b23-015eec0759a4
Local pid:
pubs:745464

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