Journal article icon

Journal article

The impact of an extended nucleobase-2′-deoxyribose linker in the biophysical and biological properties of oligonucleotides

Abstract:

Interest in artificial DNA mimetics has been triggered by the widespread applications of nucleic acids as they are useful tools for modulation of the biophysical and biological properties of oligonucleotides. In this article, we describe the synthesis and properties of a novel thymine derivative (T*) containing an extended linker between the thymine nucleobase and the 2′-deoxyribose moiety. The modified 2′-deoxyribosyl derivative was prepared via coupling of a functionalized nucleobase to the...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1039/C6RA26852H

Authors


More by this author
Role:
Author
ORCID:
0000-0002-2883-5267
More by this author
Role:
Author
ORCID:
0000-0002-7732-4543
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
ORCID:
0000-0001-6421-7733
More by this author
Role:
Author
ORCID:
0000-0003-3047-738X
Expand authors...
Publisher:
Royal Society of Chemistry Publisher's website
Journal:
RSC Advances Journal website
Volume:
7
Issue:
16
Pages:
9579-9586
Publication date:
2017-01-31
Acceptance date:
2017-01-27
DOI:
ISSN:
2046-2069
Source identifiers:
745464
Pubs id:
pubs:745464
UUID:
uuid:8779e627-f1ee-4ab8-8b23-015eec0759a4
Local pid:
pubs:745464
Deposit date:
2018-06-07

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP