Journal article

The impact of an extended nucleobase-2′-deoxyribose linker in the biophysical and biological properties of oligonucleotides

Abstract:: Interest in artificial DNA mimetics has been triggered by the widespread applications of nucleic acids as they are useful tools for modulation of the biophysical and biological properties of oligonucleotides. In this article, we describe the synthesis and properties of a novel thymine derivative (T*) containing an extended linker between the thymine nucleobase and the 2′-deoxyribose moiety. The modified 2′-deoxyribosyl derivative was prepared via coupling of a functionalized nucleobase to the...
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Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Carnero, A., Pérez-Rentero, S., Alagia, A., Aviñó, A., Sanghvi, Y., Fernández, S., Ferrero, M., & Eritja, R. (2017). The impact of an extended nucleobase-2′-deoxyribose linker in the biophysical and biological properties of oligonucleotides. RSC Advances, 7(16), 9579–9586.

MLA Style

Carnero, A., et al. “The Impact of an Extended Nucleobase-2′-Deoxyribose Linker in the Biophysical and Biological Properties of Oligonucleotides.” RSC Advances, vol. 7, no. 16, Royal Society of Chemistry, 2017, pp. 9579–86.

Chicago Style

Carnero, A, S Pérez-Rentero, A Alagia, A Aviñó, Y Sanghvi, S Fernández, M Ferrero, and R Eritja. 2017. “The Impact of an Extended Nucleobase-2′-Deoxyribose Linker in the Biophysical and Biological Properties of Oligonucleotides.” RSC Advances 7 (16): 9579–86.
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Files:: C6RA26852H.pdf

(Preview, Version of record, pdf, 760.8KB, Terms of use)

Publisher copy:: 10.1039/C6RA26852H

Authors

+ Carnero, A More by this author

Role:

Author

ORCID:

0000-0002-2883-5267

+ Pérez-Rentero, S More by this author

Role:

Author

ORCID:

0000-0002-7732-4543

+ Alagia, A More by this author

Institution:

University of Oxford

Division:

MSD

Department:

Pathology Dunn School

Role:

Author

ORCID:

0000-0001-6421-7733

+ Aviñó, A More by this author

Role:

Author

ORCID:

0000-0003-3047-738X

+ Sanghvi, Y More by this author

Role:

Author

More authors...

Funding

+ Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina More from this funder

Grant:

CB_06_0019

+ Principado de Asturias More from this funder

Grant:

FC-15-GRUPIN14-002

+ Ministerio de Ciencia e Innovación More from this funder

Grant:

CTQ2014-55015-P

Bibliographic Details

Publisher:: Royal Society of Chemistry
Journal:: RSC Advances More from this journal
Volume:: 7
Issue:: 16
Pages:: 9579-9586
Publication date:: 2017-01-31
Acceptance date:: 2017-01-27
DOI:: 10.1039/C6RA26852H
ISSN:: 2046-2069

Item Description

Pubs id:: pubs:745464
UUID:: uuid:8779e627-f1ee-4ab8-8b23-015eec0759a4
Local pid:: pubs:745464
Source identifiers:: 745464
Deposit date:: 2018-06-07

Terms of use

Copyright holder:: Carnero et al
Copyright date:: 2017
Notes:: This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Licence:: CC Attribution (CC BY)

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