Cutting edge: MHC class I triggering by a novel cell surface ligand costimulates proliferation of activated human T cells.

Journal article

BY55 is a human cell surface molecule whose expression is restricted to NK cells, a subset of circulating CD8+ T lymphocytes, and all intestinal intraepithelial T lymphocytes. Here, we report that BY55 is a novel NK receptor showing broad specificity for both classical and nonclassical MHC class I molecules, and that optimal binding requires a prior aggregation of MHC class I complexes. Using BY55 transfectants, we have identified functional consequences of MHC class I/ligand interactions for...

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Authors: Agrawal, S; Marquet, J; Freeman, G; Tawab, A; Bouteiller, P

• Publication status: Published
• Journal: Journal of Immunology
• Volume: 162
• Issue: 3
• Pages: 1223-1226
• Publication date: 1999-02-01
• EISSN: 1550-6606
• ISSN: 0022-1767
• Language: English
• Keywords: Solubility; Signal Transduction; Cell Line; Cricetinae; Receptors, Immunologic; Humans; Mice; Lymphocyte Activation; Histocompatibility Antigens Class I; Animals; Antigens, CD; Ligands; GPI-Linked Proteins; Membrane Proteins; T-Lymphocytes; Antigens, CD28; Transfection; HLA-A2 Antigen; Recombinant Proteins; Killer Cells, Natural