Monitoring disease activity and progression in primary progressive multiple sclerosis using MRI: sub-voxel registration to identify lesion changes and to detect cerebral atrophy.

Journal article

OBJECTIVE: To explore the potential usefulness of two new magnetic resonance imaging (MRI) analysis techniques for assessment of progressive cerebral atrophy and T2 lesion activity in primary progressive multiple sclerosis (PPMS), and thereby assess the relationship between MRI activity and atrophy in this patient group. BACKGROUND: Measurements of cerebral atrophy and net change in T2 lesion volumes are currently used as surrogate markers of disease progression in multiple sclerosis (MS). H...

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Authors: Stevenson, V; Smith, S; Matthews, P; Miller, D; Thompson, A

• Publication status: Published
• Journal: Journal of neurology
• Volume: 249
• Issue: 2
• Pages: 171-177
• Publication date: 2002-02-01
• DOI: 10.1007/pl00007860
• EISSN: 1432-1459
• ISSN: 0340-5354
• Language: English
• Keywords: Statistics as Topic; Adult; Middle Aged; Aged; Cerebral Cortex; Female; Disease Progression; Male; Multiple Sclerosis; Magnetic Resonance Imaging; Axons; Image Processing, Computer-Assisted; Humans; Atrophy