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Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways.

Abstract:

Through genome-wide association meta-analyses of up to 133,010 individuals of European ancestry without diabetes, including individuals newly genotyped using the Metabochip, we have increased the number of confirmed loci influencing glycemic traits to 53, of which 33 also increase type 2 diabetes risk (q < 0.05). Loci influencing fasting insulin concentration showed association with lipid levels and fat distribution, suggesting impact on insulin resistance. Gene-based analyses identified f...

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Publication status:
Published

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Publisher copy:
10.1038/ng.2385

Authors


Wheeler, E More by this author
Montasser, ME More by this author
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Journal:
Nature genetics
Volume:
44
Issue:
9
Pages:
991-1005
Publication date:
2012-09-05
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
URN:
uuid:87746d32-0f35-4b97-ae80-ca887e054840
Source identifiers:
345647
Local pid:
pubs:345647

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