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RelB/p50 regulates TNF production in LPS-stimulated dendritic cells and macrophages

Abstract:

Dendritic cells (DCs) and macrophages are effective antigen-presenting cells, and DCs, once matured, have the ability to potently activate naïve T cells. While the canonical p65/p50 NF-κB pathway seems to have an important role during LPS-stimulation of these cells, the specific contribution of the non-canonical RelB/p50 subunits is not clear yet. We aimed to investigate the relevance of this pathway in DCs and macrophages by using replication-deficient adenoviruses overexpressing RelB and p5...

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Publisher copy:
10.1016/j.cyto.2012.12.029

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
Journal:
Cytokine
Volume:
61
Issue:
3
Pages:
736-740
Publication date:
2013-03-01
DOI:
EISSN:
1096-0023
ISSN:
1043-4666
Source identifiers:
395329
Language:
English
Keywords:
Pubs id:
pubs:395329
UUID:
uuid:876b15a7-babf-49b6-a7af-66f0115ea8c2
Local pid:
pubs:395329
Deposit date:
2013-11-16

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