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Persistence and resistance as complementary bacterial adaptations to antibiotics

Abstract:

Bacterial persistence represents a simple of phenotypic heterogeneity, whereby a proportion of cells in an isogenic bacterial population can survive exposure to lethal stresses such as antibiotics. In contrast, genetically based antibiotic resistance allows for continued growth in the presence of antibiotics. It is unclear, however, whether resistance and persistence are complementary or alternative evolutionary adaptations to antibiotics. Here, we investigate the co-evolution of resistance a...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1111/jeb.12864

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Institution:
University of Oxford
Department:
Oxford, MPLS, Zoology
Role:
Author
Publisher:
Wiley Online Library Publisher's website
Journal:
Journal of evolutionary biology Journal website
Volume:
29
Issue:
6
Pages:
1223-1233
Publication date:
2016-04-06
Acceptance date:
2016-03-09
DOI:
EISSN:
1420-9101
ISSN:
1010-061X
URN:
uuid:8765ecd5-7acf-4cf6-959f-b54f6425f59f
Source identifiers:
611795
Local pid:
pubs:611795
Paper number:
6

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