- Abstract:
-
Bacterial persistence represents a simple of phenotypic heterogeneity, whereby a proportion of cells in an isogenic bacterial population can survive exposure to lethal stresses such as antibiotics. In contrast, genetically based antibiotic resistance allows for continued growth in the presence of antibiotics. It is unclear, however, whether resistance and persistence are complementary or alternative evolutionary adaptations to antibiotics. Here, we investigate the co-evolution of resistance a...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 435.1KB)
-
- Publisher copy:
- 10.1111/jeb.12864
-
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- Publisher:
- Wiley Online Library Publisher's website
- Journal:
- Journal of evolutionary biology Journal website
- Volume:
- 29
- Issue:
- 6
- Pages:
- 1223-1233
- Publication date:
- 2016-04-06
- Acceptance date:
- 2016-03-09
- DOI:
- EISSN:
-
1420-9101
- ISSN:
-
1010-061X
- URN:
-
uuid:8765ecd5-7acf-4cf6-959f-b54f6425f59f
- Source identifiers:
-
611795
- Local pid:
- pubs:611795
- Paper number:
- 6
- Language:
- English
- Keywords:
- Copyright holder:
- Tom Vogwill et al.
- Copyright date:
- 2016
- Notes:
- This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
Journal article
Persistence and resistance as complementary bacterial adaptations to antibiotics
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