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Stabilization of influenza virus replication intermediates is dependent on the RNA-binding but not the homo-oligomerization activity of the viral nucleoprotein.

Abstract:

The influenza virus nucleoprotein (NP) is believed to play a central role in directing a switch from RNA genome transcription to replication by the viral RNA polymerase. However, this role has recently been disputed with the proposal of alternative regulatory mechanisms. It has been suggested that the expression of viral polymerase and NP allows genome replication by stabilization of cRNA replication intermediates and complementary ribonucleoprotein (cRNP) assembly. Here, we demonstrate that ...

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Publication status:
Published

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Publisher copy:
10.1128/jvi.00695-11

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Journal:
Journal of virology
Volume:
85
Issue:
22
Pages:
12073-12078
Publication date:
2011-11-05
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
URN:
uuid:8758606c-b867-456e-81e2-f10be791ff53
Source identifiers:
175232
Local pid:
pubs:175232

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