- Abstract:
-
Despite high-hyperdiploid acute lymphoblastic leukaemia (HD-ALL) being the most common subgroup of paediatric ALL, its aetiology remains unknown. Genome-wide association studies have demonstrated association at 10q21.2. Here, we sought to determine how this region influences HD-ALL risk. We impute genotypes across the locus, finding the single nucleotide polymorphism rs7090445 highly associated with HD-ALL (P=1.54 × 10-38), and residing in a predicted enhancer element. We show this region phy...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher version
- Files:
-
-
(pdf, 132.2kb)
-
(pdf, 745.0kb)
-
- Publisher copy:
- 10.1038/ncomms14616
-
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- Publisher:
- Springer Nature Publisher's website
- Journal:
- Nature communications Journal website
- Volume:
- 8
- Pages:
- 14616
- Publication date:
- 2017-03-03
- Acceptance date:
- 2017-01-17
- DOI:
- ISSN:
-
2041-1723
- Pubs id:
-
pubs:737689
- URN:
-
uri:873c9d9d-3e82-4e3a-a05d-3435c54936d5
- UUID:
-
uuid:873c9d9d-3e82-4e3a-a05d-3435c54936d5
- Local pid:
- pubs:737689
- Language:
- English
- Keywords:
- Copyright holder:
- Studd et al.
- Copyright date:
- 2017
- Notes:
- Copyright The Author(s) 2017. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. A correction note to this article is available at: https://www.nature.com/articles/ncomms16204.
Journal article
Genetic and regulatory mechanism of susceptibility to high-hyperdiploid acute lymphoblastic leukaemia at 10p21.2
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