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Genetic and regulatory mechanism of susceptibility to high-hyperdiploid acute lymphoblastic leukaemia at 10p21.2

Abstract:

Despite high-hyperdiploid acute lymphoblastic leukaemia (HD-ALL) being the most common subgroup of paediatric ALL, its aetiology remains unknown. Genome-wide association studies have demonstrated association at 10q21.2. Here, we sought to determine how this region influences HD-ALL risk. We impute genotypes across the locus, finding the single nucleotide polymorphism rs7090445 highly associated with HD-ALL (P=1.54 × 10-38), and residing in a predicted enhancer element. We show this region phy...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher version

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Publisher copy:
10.1038/ncomms14616

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ORCID:
0000-0002-7157-754X
Vijayakrishnan, J More by this author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Human Genetics Wt Centre
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ORCID:
0000-0001-7950-222X
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Swedish Childhood Cancer Foundation More from this funder
Publisher:
Springer Nature Publisher's website
Journal:
Nature communications Journal website
Volume:
8
Pages:
14616
Publication date:
2017-03-03
Acceptance date:
2017-01-17
DOI:
ISSN:
2041-1723
Pubs id:
pubs:737689
URN:
uri:873c9d9d-3e82-4e3a-a05d-3435c54936d5
UUID:
uuid:873c9d9d-3e82-4e3a-a05d-3435c54936d5
Local pid:
pubs:737689
Language:
English
Keywords:

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