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N-butyldeoxynojirimycin causes weight loss as a result of appetite suppression in lean and obese mice.

Abstract:

AIM: To determine the mechanism of weight loss caused by high doses of N-butyldeoxynojirimycin (NB-DNJ) in healthy lean and leptin-deficient obese (ob/ob) mice. METHODS: Healthy lean and obese mice were treated with NB-DNJ by the following methods: admixed with their diet, delivered by subcutaneously implanted mini-pumps or by intraperitoneal or intracerebroventricular (ICV) injection. Daily changes in body weight and food intake were recorded during the experimental period. The effect of NB...

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Publication status:
Published

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Authors


Priestman, DA More by this author
van der Spoel, AC More by this author
Butters, TD More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Journal:
Diabetes, obesity and metabolism
Volume:
10
Issue:
2
Pages:
159-166
Publication date:
2008-02-05
DOI:
EISSN:
1463-1326
ISSN:
1462-8902
URN:
uuid:873ac00f-8df6-40e5-af74-17477a19f0ab
Source identifiers:
101075
Local pid:
pubs:101075

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