Maternal transmission of multiple sclerosis in a dutch population.

Journal article

OBJECTIVE: To investigate the parental relationship of patients with multiple sclerosis (MS) from an extended pedigree with extensive genealogical information up to the middle of the 18th century. DESIGN: Multiple sclerosis is a complex disease resulting from genetic and environmental factors. Parent-of-origin effect, a phenomenon when the same allele may express differently depending on the sex of the transmitting parent, may influence the risk for MS. We investigated parental relationships...

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Authors: Hoppenbrouwers, I; Liu, F; Aulchenko, Y; Ebers, G; Oostra, B

• Publication status: Published
• Journal: Archives of neurology
• Volume: 65
• Issue: 3
• Pages: 345-348
• Publication date: 2008-03-01
• DOI: 10.1001/archneurol.2007.63
• EISSN: 1538-3687
• ISSN: 0003-9942
• Language: English
• Keywords: Pedigree; Humans; Middle Aged; Genetic Predisposition to Disease; Adult; Multiple Sclerosis; Risk Factors; Inheritance Patterns; Odds Ratio; Sex Characteristics; Sex Factors; Mothers; Female; Netherlands; Male