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Journal article

Synthetic α- and β-Ser-ADP-ribosylated peptides reveal α-Ser-ADPr as the native epimer

Abstract:

A solid-phase methodology to synthesize oligopeptides, specifically incorporating serine residues linked to ADP-ribose (ADPr), is presented. Through the synthesis of both α- and β-anomers of the phosphoribosylated Fmoc-Ser building block and their usage in our modified solid-phase peptide synthesis protocol, both α- and β-ADPr peptides from a naturally Ser-ADPr containing H2B sequence were obtained. With these, and by digestion studies using the human glycohydrolase, ARH3 (hARH3), compelling ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1021/acs.orglett.8b01742

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences
Department:
Pathology Dunn School
Role:
Author
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Publisher:
American Chemical Society Publisher's website
Journal:
Organic Letters Journal website
Volume:
20
Issue:
13
Pages:
4140-4143
Publication date:
2018-06-27
Acceptance date:
2018-06-27
DOI:
EISSN:
1523-7052
ISSN:
1523-7060
Source identifiers:
864373
Pubs id:
pubs:864373
UUID:
uuid:8716cfe9-a46b-4022-b2a6-b4510d91d399
Local pid:
pubs:864373
Deposit date:
2018-07-04

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