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Modeling chemotaxis reveals the role of reversed phosphotransfer & a bi-functional kinase-phosphatase

Abstract:

Understanding how multiple signals are integrated in living cells to produce a balanced response is a major challenge in biology. Two-component signal transduction pathways, such as bacterial chemotaxis, comprise histidine protein kinases (HPKs) and response regulators (RRs). These are used to sense and respond to changes in the environment. Rhodobacter sphaeroides has a complex chemosensory network with two signaling clusters, each containing a HPK, CheA. Here we demonstrate, using a mathema...

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Publication date:
2010-01-01
URN:
uuid:8714eb01-b361-4170-acc5-f5529cf6d4d0
Local pid:
oai:eprints.maths.ox.ac.uk:969

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