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A CD4(+) T-cell immune response to a conserved epitope in the circumsporozoite protein correlates with protection from natural Plasmodium falciparum infection and disease.

Abstract:

Many human T-cell responses specific for epitopes in Plasmodium falciparum have been described, but none has yet been shown to be predictive of protection against natural malaria infection. Here we report a peptide-specific T-cell assay that is strongly associated with protection of humans in The Gambia, West Africa, from both malaria infection and disease. The assay detects interferon-gamma-secreting CD4(+) T cells specific for a conserved sequence from the circumsporozoite protein, which bi...

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Publication status:
Published

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Publisher copy:
10.1038/nm1009

Authors


Gothard, PK More by this author
Milligan, P More by this author
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Journal:
Nature medicine
Volume:
10
Issue:
4
Pages:
406-410
Publication date:
2004-04-05
DOI:
EISSN:
1546-170X
ISSN:
1078-8956
URN:
uuid:87145657-feb3-42c2-bd8f-5a58dd0df2d6
Source identifiers:
31297
Local pid:
pubs:31297

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