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Striatal dopamine transmission is reduced after chronic nicotine with a decrease in α6-nicotinic receptor control in nucleus accumbens.

Abstract:

Nicotine directly regulates striatal dopamine (DA) neurotransmission via presynaptic nicotinic acetylcholine receptors (nAChRs) that are α6β2 and/or α4β2 subunit-containing, depending on region. Chronic nicotine exposure in smokers upregulates striatal nAChR density, with some reports suggesting differential impact on α6- or α4-containing nAChRs. Here, we explored whether chronic nicotine exposure modifies striatal DA transmission, whether the effects of acute nicotine on DA release probabili...

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Publication status:
Published

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Publisher copy:
10.1111/ejn.12298

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Journal:
European journal of neuroscience
Volume:
38
Issue:
7
Pages:
3036-3043
Publication date:
2013-07-01
DOI:
EISSN:
1460-9568
ISSN:
0953-816X
Source identifiers:
411149
Language:
English
Keywords:
Pubs id:
pubs:411149
UUID:
uuid:87133cbb-83d2-44d4-abeb-860552be96a4
Local pid:
pubs:411149
Deposit date:
2013-11-16

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