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Inhibition of lymphangiogenesis with resulting lymphedema in transgenic mice expressing soluble VEGF receptor-3.

Abstract:

The lymphatic vasculature transports extravasated tissue fluid, macromolecules and cells back into the blood circulation. Recent reports have focused on the molecular mechanisms regulating the lymphatic vessels. Vascular endothelial growth factor (VEGF)-C and VEGF-D have been shown to stimulate lymphangiogenesis and their receptor, VEGFR-3, has been linked to human hereditary lymphedema. Here we show that a soluble form of VEGFR-3 is a potent inhibitor of VEGF-C/VEGF-D signaling, and when exp...

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Publication status:
Published

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Publisher copy:
10.1038/84651

Authors


Mäkinen, T More by this author
Jussila, L More by this author
Veikkola, T More by this author
Karpanen, T More by this author
Kettunen, MI More by this author
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Journal:
Nature medicine
Volume:
7
Issue:
2
Pages:
199-205
Publication date:
2001-02-05
DOI:
EISSN:
1546-170X
ISSN:
1078-8956
URN:
uuid:871297f7-813b-450e-932b-f47ea1092af0
Source identifiers:
102530
Local pid:
pubs:102530

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